The Sievers 500 RL On-Line Total Organic Carbon (TOC) Analyzer was designed to continuously monitor organics in ultrapure water for real-time release, cleaning validation and other pharmaceutical applications.
Sievers 500 RL Overview
Continuous Online Monitoring of TOC
The Sievers 500 RL On-Line Total Organic Carbon (TOC) Analyzer is a reagentless analyzer designed to continuously monitor organics in ultrapure water for pharmaceutical, microelectronics, semiconductor, and power applications. The Sievers 500 RL On-Line TOC Analyzer provides the superior analytical accuracy and performance found in all Sievers TOC Analyzers, with a 0.03 ppb limit of detection and autozero capabilities for unsurpassed low-level performance. The 500 RL TOC Analyzer provides a range of options, including the innovative 4-port Super iOS standards introduction device, that can be customized to meet the specific needs of a wide variety of applications.
Compliance with Japanese (JP16) and Other Global Pharmacopeias
The Sievers 500 RL, along with the Sievers 900 Series, now offer integrated firmware and software support to meet the new Japanese Pharmacopeia 16 (JP16), JP<2.59> TOC Test and JP<2.51> Conductivity Test (Model 500 RL only) requirements for Purified Water (PW) and Water for Injection (WFI). The JP <2.59> TOC standard requires different compounds and calculations for calibration and system suitability testing than those specified in the USP and EP monographs. The Sievers 500 RL and 900 Series TOC Analyzers support all other major global pharmacopeias, including the United States Pharmacopeia (USP), European Pharmacopeia (EP), Chinese Pharmacopeia (CP), and the Indian Pharmacopeia (IP).
For more information, read the application note, "Compliance with JP 16 TOC Requirements Using the Sievers 900 and 500 RL TOC Analyzers and Standards."
Designed for Real-time Water Release (RTR)
The Sievers 500 RL On-Line TOC Analyzer is designed to deliver science-based risk management capability to the production floor. It integrates the trusted Sievers laboratory TOC analysis methodology into a reagentless on-line analyzer that delivers the same high level of analytical process capability associated with laboratory analyzers, but without the delay. The 500 RL thus supports pharmaceutical industry quality initiatives such as Process Analytical Technology (PAT), Real-time Release (RTR), and on-line Cleaning Validation.